An Allelic Po lymorphism within the H u m a n Tumor Necrosis Factor ol Promoter Region Is Strongly Associated with H LA A 1 , B 8 , and D R 3 Alleles
نویسنده
چکیده
The tumor necrosis factor (TNF) c~ gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-ct locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-o~ polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLAtyped individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-ct and other MHC alleles and raises the possibility that the uncommon TNF-ct allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype.
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